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vicissitude noun

  /vaɪˈsɪs.ɪˌtuːd/ , /vɪˈsɪs.ɪˌt(j)uːd/
  • Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange; variability.
  • (often, in the plural) A change, especially in one's life or fortunes.
 vicisitud
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